NPC1L1

Across TCGA patient cohorts, NPC1L1 mutation is significantly associated with the total protein of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPC1L1-associated genes across cancer lineages are ASNS, EGFR_pY1068, and eIF4E. Each is linked with NPC1L1 in more than 3 cancer types. Because this analysis shows association rather than direction, both NPC1L1-to-partner and partner-to-NPC1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by NPC1L1-low versus NPC1L1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPC1L1→partner) and Y-score (partner→NPC1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.615	+3.584	<.001	.002	3	4
UCEC	EGFR_pY1068 →	-0.156	-1.058	.035	.037	3	3
UCEC	eIF4E →	+0.183	+3.713	.003	<.001	3	3
UCEC	JNK_pT183_Y185 →	-0.120	-1.584	.015	.017	3	3
UCEC	MEK1 →	+0.455	+2.099	<.001	<.001	3	3
UCEC	Notch1 →	+0.184	+3.261	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

ASNS by NPC1L1 expression — COAD

Explore this box plot interactively →