NPC1L1

Across TCGA cell cohorts, NPC1L1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,751 significant associations in total. LIVER shows the largest number of these associations.

The most reproducible NPC1L1-associated GO terms across cancer lineages are Energy derivation by oxidation of organic compounds, Establishment of protein localization to endoplasmic reticulum, and Regulation of macroautophagy. Each is linked with NPC1L1 in more than 5 cancer types. Because this analysis shows association rather than direction, both NPC1L1-to-partner and partner-to-NPC1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Energy derivation by oxidation of organic compounds grouped by NPC1L1-low versus NPC1L1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NPC1L1→partner) and Y-score (partner→NPC1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Energy derivation by oxidation of organic compounds →	+0.037	+0.981	.004	.005	3	6
PANCREAS	Establishment of protein localization to endoplasmic reticulum →	+0.087	+0.121	<.001	.002	3	6
OESOPHAGUS	Regulation of macroautophagy →	+0.058	+0.216	.001	.001	3	6
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.121	+0.266	.001	.002	3	6
LIVER	Fructose catabolic process →	+0.314	+2.578	<.001	.001	3	5
OESOPHAGUS	Mitochondrial electron transport, cytochrome c to oxygen →	+0.115	+0.242	<.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,751 associations by consensus.

Energy derivation by oxidation of organic compounds by NPC1L1 expression — LUNG_SCLC

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