Across TCGA cell cohorts, NPB mutation is significantly associated with the mutation status of many other genes, with 1,120 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NPB-associated genes across cancer lineages are ESCO2, CABP4, and SLC6A8. Each is linked with NPB in more than 2 cancer types. Because this analysis shows association rather than direction, both NPB-to-partner and partner-to-NPB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPB→partner) and Y-score (partner→NPB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ESCO2 →	+5.321	+5.894	.002	.002	1	3
BLOOD_Leukemia	CABP4 →	+4.321	+5.285	.005	.005	1	3
BLOOD_Leukemia	SLC6A8 →	+4.000	+5.050	.008	.008	1	3
BLOOD_Leukemia	SH3GLB2 →	+5.321	+5.894	.002	.002	1	3
BLOOD_Leukemia	SUMO3 →	+6.321	+6.321	.001	.001	1	2
BLOOD_Leukemia	MAPK11 →	+4.736	+5.560	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,120 associations by consensus.

Exploration

NPB survival (RNA) · tumor vs normal (RNA) · all NPB data types