NPAS4

Across TCGA patient cohorts, NPAS4 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPAS4-associated genes across cancer lineages are Shc_pY317, Cyclin-B1, and Caspase-7-cleavedD198. Each is linked with NPAS4 in more than 3 cancer types. Because this analysis shows association rather than direction, both NPAS4-to-partner and partner-to-NPAS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by NPAS4-low versus NPAS4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPAS4→partner) and Y-score (partner→NPAS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.119	-1.777	.013	.002	3	4
UCEC	Cyclin-B1 →	+0.657	+2.378	<.001	<.001	3	4
UCEC	Caspase-7-cleavedD198 →	+0.728	+2.682	<.001	<.001	3	3
SKCM	MYH11 →	-0.669	-1.432	.008	.004	3	2
SKCM	NDRG1_pT346 →	-0.464	-2.000	.017	.007	3	2
SKCM	p38-MAPK_pT180_Y182 →	-0.235	-2.205	.022	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Shc_pY317 by NPAS4 expression — UCEC

Explore this box plot interactively →