NPAS4

Across TCGA cell cohorts, NPAS4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,522 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible NPAS4-associated GO terms across cancer lineages are Trophectodermal cell differentiation, Positive regulation of actin filament bundle assembly, and Error-free translesion synthesis. Each is linked with NPAS4 in more than 6 cancer types. Because this analysis shows association rather than direction, both NPAS4-to-partner and partner-to-NPAS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Trophectodermal cell differentiation grouped by NPAS4-low versus NPAS4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NPAS4→partner) and Y-score (partner→NPAS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Trophectodermal cell differentiation →	+0.163	+0.602	<.001	.005	3	6
LARGE_INTESTINE	Positive regulation of actin filament bundle assembly →	+0.047	+0.014	.003	.002	3	6
BONE	Error-free translesion synthesis →	+0.111	+0.680	.004	.007	2	7
BONE	Calcium-independent cell-matrix adhesion →	+0.263	+0.497	<.001	.003	3	6
LUNG_SCLC	Negative regulation of cell cycle process →	+0.038	+0.834	.001	.004	3	5
LUNG_SCLC	Regulation of protein folding →	+0.075	+0.809	.005	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,522 associations by consensus.

Trophectodermal cell differentiation by NPAS4 expression — BONE

Explore this box plot interactively →