NPAS4

Across TCGA cell cohorts, NPAS4 mutation is significantly associated with the mutation status of many other genes, with 4,437 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPAS4-associated genes across cancer lineages are DNAH2, NF1, and PCDHA1. Each is linked with NPAS4 in more than 4 cancer types. Because this analysis shows association rather than direction, both NPAS4-to-partner and partner-to-NPAS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAH2 grouped by NPAS4-low versus NPAS4-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPAS4→partner) and Y-score (partner→NPAS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DNAH2 →	+2.514	+2.925	.007	.007	1	5
LARGE_INTESTINE	NF1 →	+1.931	+3.280	<.001	<.001	1	5
LARGE_INTESTINE	PCDHA1 →	+2.632	+3.273	<.001	<.001	1	5
BLOOD_Leukemia	ADCY10 →	+2.997	+3.697	<.001	<.001	1	5
SKIN	NPC1L1 →	+3.357	+3.532	.005	.005	1	5
SKIN	PEAK1 →	+3.357	+3.532	.005	.005	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,437 associations by consensus.

DNAH2 by NPAS4 expression — OVARY

Explore this box plot interactively →