NPAS2-AS1

Across TCGA pan-cancer cohorts, NPAS2-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated NPAS2-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NPAS2-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NPAS2-AS1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and ESCA show a favorable association.

KIRC, UCEC, and ACC are the cancer types where NPAS2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	II,III,IV	0.387	0.665	<.001	71	view →
UCEC	OS	Median	All	0.899	0.952	<.001	58	view →
ACC	OS	Tertile	All	0.631	0.898	<.001	43	view →
LUAD	DFS	Tertile	All	0.257	0.433	.007	24	view →
READ	OS	Median	IV	0.538	0.875	.006	21	view →
CHOL	DFS	Quartile	All	0.102	0.660	.011	21	view →
PAAD	DFS	Median	All	0.601	0.356	<.001	17	view →
KIRP	OS	Median	III,IV	0.307	0.624	.010	15	view →
CESC	DFS	Quartile	All	0.715	0.861	.004	14	view →
LGG	DFS	Quartile	All	0.208	0.430	<.001	12	view →
ESCA	OS	Quartile	III,IV	0.673	0.362	.007	6	view →
BLCA	OS	Median	IV	0.674	0.514	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

NPAS2-AS1–KIRC (OS)

Open the KIRC breakdown →