NPAS2-AS1

Across TCGA pan-cancer cohorts, NPAS2-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of NPAS2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NPAS2-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NPAS2-AS1 is over-expressed in tumor, although a few such as STAD and KICH show the opposite, repressed pattern.

HNSC, COAD, and UCEC are the cancer types where NPAS2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPAS2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.096	.004	8	view →
COAD	All	All	+0.110	<.001	7	view →
UCEC	All	III,IV	+0.256	.008	6	view →
THCA	Male	III,IV	+0.111	.009	6	view →
LUAD	All	All	+0.199	<.001	5	view →
CHOL	All	All	+0.367	.010	2	view →
STAD	Female	III,IV	−0.455	.023	1	view →
LUSC	Male	All	+0.056	.038	1	view →
KICH	All	All	−0.052	.034	1	view →
LIHC	All	All	+0.021	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

NPAS2-AS1–HNSC

Open the HNSC breakdown →