NPAS1

Across TCGA cell cohorts, NPAS1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NPAS1-associated genes across cancer lineages are VSTM2B, TEX48, and PSKH2. Each is linked with NPAS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPAS1-to-partner and partner-to-NPAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VSTM2B grouped by NPAS1-low versus NPAS1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPAS1→partner) and Y-score (partner→NPAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VSTM2B →	+0.063	+3.289	<.001	.009	3	1
BLOOD_Leukemia	TEX48 →	+0.042	+4.475	<.001	<.001	3	1
LUNG_NSCLC_LUAD	PSKH2 →	+0.031	+4.887	<.001	.009	3	1
SKIN	IL22RA2 →	+0.016	+4.688	<.001	<.001	3	1
BLOOD_Leukemia	LRRC38 →	+1.281	+3.631	.002	.006	2	1
BLOOD_Leukemia	SYT9 →	+0.159	+4.349	<.001	<.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

VSTM2B by NPAS1 expression — BLOOD_Leukemia

Explore this box plot interactively →