NOX4

Across TCGA cell cohorts, NOX4 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NOX4-associated genes across cancer lineages are OR5B12, OR8B8, and TINAG. Each is linked with NOX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOX4-to-partner and partner-to-NOX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5B12 grouped by NOX4-low versus NOX4-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOX4→partner) and Y-score (partner→NOX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR5B12 →	+0.047	+3.523	<.001	.008	3	2
BLOOD_Leukemia	OR8B8 →	+0.018	+5.201	.006	.006	3	2
LUNG_SCLC	TINAG →	+1.212	+3.807	<.001	.006	3	1
LUNG_SCLC	OR2T12 →	+0.099	+3.817	<.001	.004	3	1
LUNG_SCLC	OR5T2 →	+0.012	+4.058	<.001	.007	3	1
LUNG_SCLC	KRTAP6-1 →	+0.042	+4.058	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

OR5B12 by NOX4 expression — LUNG_SCLC

Explore this box plot interactively →