NOX3

Across TCGA patient cohorts, NOX3 mutation is significantly associated with the RNA expression of many other genes, with 1,789 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOX3-associated genes across cancer lineages are LAPTM4BP2, KCNK5, and ATAD3A. Each is linked with NOX3 in more than 2 cancer types. Because this analysis shows association rather than direction, both NOX3-to-partner and partner-to-NOX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LAPTM4BP2 grouped by NOX3-low versus NOX3-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOX3→partner) and Y-score (partner→NOX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	LAPTM4BP2 →	+0.083	+3.698	<.001	.001	3	3
UCEC	KCNK5 →	-0.670	-2.226	.004	.002	3	3
SKCM	ATAD3A →	+0.575	+2.353	.001	.003	3	3
LUAD	SOX1-OT →	+0.377	+2.252	.006	.008	3	3
SKCM	LINC01763 →	+0.153	+2.311	.002	.001	3	3
HNSC	MIR4716 →	+0.210	+4.936	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,789 associations by consensus.

LAPTM4BP2 by NOX3 expression — LIHC

Explore this box plot interactively →