NOX3

Across TCGA pan-cancer cohorts, NOX3 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated NOX3 data layer compared with 5 for mutation status.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher NOX3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NOX3 expression acts as an unfavorable survival marker, although some lineages such as LGG and STAD show a favorable association.

UCS, CHOL, and ACC are the cancer types where NOX3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	II,III,IV	0.162	0.508	.002	72	view →
CHOL	DFS	Tertile	All	0.092	0.523	<.001	45	view →
ACC	DFS	Tertile	All	0.328	0.667	<.001	39	view →
CESC	OS	Tertile	IV	0.091	0.593	<.001	36	view →
LIHC	OS	Tertile	II,III,IV	0.423	0.732	<.001	36	view →
LGG	DFS	Median	All	0.887	0.782	<.001	23	view →
STAD	OS	Tertile	IV	0.698	0.350	.020	21	view →
PAAD	DFS	Tertile	All	0.202	0.381	.032	18	view →
MESO	OS	Tertile	IV	0.077	0.592	.019	18	view →
KIRC	DFS	Quartile	III,IV	0.500	0.659	.031	16	view →
LUAD	DFS	Tertile	All	0.834	0.307	.009	12	view →
PCPG	DFS	Median	All	0.958	0.817	.004	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

NOX3–UCS (DFS)

Open the UCS breakdown →