NOX3

Across TCGA patient cohorts, NOX3 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOX3-associated genes across cancer lineages are Notch1, Tuberin_pT1462, and 4E-BP1. Each is linked with NOX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOX3-to-partner and partner-to-NOX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by NOX3-low versus NOX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOX3→partner) and Y-score (partner→NOX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.162	+1.906	.004	.016	3	2
LUAD	Tuberin_pT1462 →	-0.277	-3.169	.004	.019	3	1
UCEC	4E-BP1 →	+0.398	+3.489	<.001	.002	2	2
UCEC	ERK2 →	+0.192	+2.000	.013	.030	3	1
UCEC	INPP4B →	-0.273	-2.321	.036	.033	3	1
UCEC	Ku80 →	+0.188	+1.498	.048	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Notch1 by NOX3 expression — UCEC

Explore this box plot interactively →