NOX3

Across TCGA cell cohorts, NOX3 mutation is significantly associated with the RNA expression of many other genes, with 880 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NOX3-associated genes across cancer lineages are GP2, MOS, and CFC1B. Each is linked with NOX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOX3-to-partner and partner-to-NOX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GP2 grouped by NOX3-low versus NOX3-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOX3→partner) and Y-score (partner→NOX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	GP2 →	+0.026	+4.807	<.001	.006	3	1
BLOOD_Myeloma	MOS →	+0.040	+4.807	<.001	.006	3	1
BREAST	CFC1B →	+0.006	+5.781	<.001	.001	3	1
LARGE_INTESTINE	GCAT →	+1.263	+2.115	<.001	.001	3	1
LARGE_INTESTINE	EIF3L →	+0.540	+2.874	<.001	<.001	3	1
LARGE_INTESTINE	DEPDC5 →	+0.580	+2.459	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 880 associations by consensus.

GP2 by NOX3 expression — BLOOD_Myeloma

Explore this box plot interactively →