NOX1

Across TCGA patient cohorts, NOX1 mutation is significantly associated with the RNA expression of many other genes, with 4,735 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOX1-associated genes across cancer lineages are DEFB127, MIR7156, and LCEP4. Each is linked with NOX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NOX1-to-partner and partner-to-NOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB127 grouped by NOX1-low versus NOX1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOX1→partner) and Y-score (partner→NOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	DEFB127 →	+0.274	+5.918	<.001	<.001	3	3
HNSC	MIR7156 →	+0.791	+5.435	<.001	.005	3	3
LUAD	LCEP4 →	+0.703	+4.928	<.001	<.001	3	3
SKCM	RNU6-1131P →	+0.090	+5.232	<.001	<.001	3	3
HNSC	MIR520G →	+0.373	+6.008	<.001	.002	3	3
LUSC	RNA5SP248 →	+0.476	+3.485	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,735 associations by consensus.

DEFB127 by NOX1 expression — LUSC

Explore this box plot interactively →