NOX1

Across TCGA pan-cancer cohorts, NOX1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated NOX1 data layer compared with 6 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher NOX1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated NOX1 expression acts as an unfavorable survival marker, although some lineages such as MESO and COAD show a favorable association.

MESO, UVM, and COAD are the cancer types where NOX1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	III,IV	0.498	0.278	.003	93	view →
UVM	DFS	Quartile	III,IV	0.202	0.922	<.001	85	view →
COAD	DFS	Median	II,III,IV	0.718	0.594	.008	49	view →
LIHC	OS	Median	All	0.704	0.851	<.001	47	view →
KIRC	DFS	Quartile	II,III,IV	0.730	0.840	.009	38	view →
LUSC	OS	Tertile	All	0.849	0.731	.002	37	view →
UCS	DFS	Median	IV	0.367	0.952	.001	36	view →
CESC	OS	Quartile	All	0.965	0.830	.001	32	view →
PRAD	OS	Tertile	All	1.000	0.760	.004	22	view →
READ	OS	Median	II,III,IV	0.845	0.320	.011	21	view →
ACC	OS	Median	III,IV	0.728	0.201	.009	21	view →
DLBC	OS	Tertile	IV	0.433	1.000	.017	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

NOX1–MESO (OS)

Open the MESO breakdown →