NOX1

Across TCGA patient cohorts, NOX1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOX1-associated genes across cancer lineages are ERCC1, ERK2, and p62 Lck ligand. Each is linked with NOX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOX1-to-partner and partner-to-NOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERCC1 grouped by NOX1-low versus NOX1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOX1→partner) and Y-score (partner→NOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ERCC1 →	+0.204	+2.824	.039	.036	3	2
UCEC	ERK2 →	+0.165	+1.925	.004	.004	3	2
UCEC	p62 Lck ligand →	+0.360	+2.999	<.001	<.001	3	2
UCEC	C-Raf →	+0.149	+2.070	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.081	-1.388	.007	.041	3	1
UCEC	EGFR_pY1068 →	-0.272	-3.087	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

ERCC1 by NOX1 expression — SKCM

Explore this box plot interactively →