NOX1

Across TCGA cell cohorts, NOX1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible NOX1-associated genes across cancer lineages are BHLHE23, SOX14, and FABP12. Each is linked with NOX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOX1-to-partner and partner-to-NOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BHLHE23 grouped by NOX1-low versus NOX1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOX1→partner) and Y-score (partner→NOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	BHLHE23 →	+0.066	+3.142	<.001	.008	3	1
SOFT_TISSUE	SOX14 →	+0.613	+3.297	.001	.008	3	1
SOFT_TISSUE	FABP12 →	+0.080	+3.584	<.001	.004	3	1
SOFT_TISSUE	BHLHA9 →	+0.018	+3.977	<.001	.007	3	1
BLOOD_Lymphoma	OR5A1 →	+0.029	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	PRAMEF10 →	+0.036	+6.247	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

BHLHE23 by NOX1 expression — SOFT_TISSUE

Explore this box plot interactively →