NOVA1

Across TCGA patient cohorts, NOVA1 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOVA1-associated genes across cancer lineages are PAI-1, Cyclin-E2, and PCNA. Each is linked with NOVA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NOVA1-to-partner and partner-to-NOVA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAI-1 grouped by NOVA1-low versus NOVA1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOVA1→partner) and Y-score (partner→NOVA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PAI-1 →	+0.792	+2.584	.009	.011	3	3
LUAD	Cyclin-E2 →	+0.143	+1.891	.016	.030	3	3
UCEC	PCNA →	+0.198	+1.836	<.001	.001	3	3
SKCM	TFRC →	+0.492	+1.700	.013	.040	3	3
LUAD	EGFR_pY1068 →	-0.541	-3.321	.010	.009	3	2
LUAD	EGFR →	-0.249	-3.169	.027	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

PAI-1 by NOVA1 expression — LUAD

Explore this box plot interactively →