Across TCGA patient cohorts, NOTUM RNA expression is significantly associated with the go_rna of many other GO terms, with 7,117 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible NOTUM-associated GO terms across cancer lineages are Dorsal/ventral axis specification, Mitral valve development, and Negative regulation of morphogenesis of an epithelium. Each is linked with NOTUM in more than 21 cancer types. Because this analysis shows association rather than direction, both NOTUM-to-partner and partner-to-NOTUM results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTUM→partner) and Y-score (partner→NOTUM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	Dorsal/ventral axis specification →	+0.057	+0.573	<.001	.006	1	22
TGCT	Mitral valve development →	+0.082	+1.356	<.001	<.001	3	20
TGCT	Negative regulation of morphogenesis of an epithelium →	+0.114	+1.313	<.001	<.001	3	20
ACC	Regulation of chondrocyte development →	+0.080	+2.304	<.001	<.001	3	18
TGCT	Regulation of prostatic bud formation →	+0.122	+1.178	<.001	<.001	3	17
TGCT	Cardiac septum morphogenesis →	+0.083	+1.352	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,117 associations by consensus.

Exploration

NOTUM survival (RNA) · tumor vs normal (RNA) · all NOTUM data types