Across TCGA pan-cancer cohorts, NOTUM RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NOTUM’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NOTUM RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NOTUM is over-expressed in tumor, although a few such as LUAD and KIRC show the opposite, repressed pattern.
HNSC, COAD, and LUAD are the cancer types where NOTUM tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NOTUM RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.