Across TCGA patient cohorts, NOTUM protein abundance is significantly associated with the RNA expression of many other genes, with 2,948 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOTUM-associated genes across cancer lineages are RCAN2, CNTN1, and ACSS3. Each is linked with NOTUM in more than 1 cancer types. Because this analysis shows association rather than direction, both NOTUM-to-partner and partner-to-NOTUM results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTUM→partner) and Y-score (partner→NOTUM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RCAN2 →	+1.230	+0.848	.006	.006	3	2
OV	CNTN1 →	+2.360	+0.897	.006	.009	3	2
UCEC	ACSS3 →	+1.775	+1.345	<.001	<.001	3	2
HNSC	PHC1 →	+1.420	+1.712	.001	.004	3	2
HNSC	EPM2A →	+0.897	+1.367	<.001	.003	3	2
HNSC	SMOC2 →	+2.739	+1.730	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,948 associations by consensus.

Exploration

NOTUM survival (RNA) · tumor vs normal (RNA) · all NOTUM data types