Across TCGA patient cohorts, NOTUM protein abundance is significantly associated with the protein abundance of many other proteins, with 2,818 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOTUM-associated proteins across cancer lineages are VAV1, CASKIN2_S403, and AKAP12_S887. Each is linked with NOTUM in more than 1 cancer types. Because this analysis shows association rather than direction, both NOTUM-to-partner and partner-to-NOTUM results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTUM→partner) and Y-score (partner→NOTUM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VAV1 →	-0.745	-1.186	<.001	<.001	3	2
OV	CASKIN2_S403 →	+1.229	+0.735	.001	.003	3	1
OV	AKAP12_S887 →	+2.015	+0.821	.003	.002	2	2
LSCC	DNAH11 →	-0.708	-0.425	.004	.003	3	1
HNSC	NIPSNAP2 →	+0.543	+1.367	.002	.003	3	1
HNSC	ARHGEF40 →	+0.707	+1.730	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,818 associations by consensus.

Exploration

NOTUM survival (RNA) · tumor vs normal (RNA) · all NOTUM data types