Across TCGA patient cohorts, NOTUM mutation is significantly associated with the RNA expression of many other genes, with 886 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible NOTUM-associated genes across cancer lineages are OR10T2, RNU6-1062P, and RNA5SP105. Each is linked with NOTUM in more than 2 cancer types. Because this analysis shows association rather than direction, both NOTUM-to-partner and partner-to-NOTUM results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTUM→partner) and Y-score (partner→NOTUM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	OR10T2 →	+0.262	+4.191	<.001	.009	3	3
LUSC	RNU6-1062P →	+0.756	+3.372	<.001	.007	3	3
LUSC	RNA5SP105 →	+0.436	+6.924	<.001	<.001	3	3
LUSC	RPSAP37 →	+0.351	+4.309	<.001	.007	3	3
CESC	MDFIC2 →	+0.055	+5.144	<.001	.003	3	2
SKCM	MTND2P8 →	+0.022	+2.547	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 886 associations by consensus.

Exploration

NOTUM survival (RNA) · tumor vs normal (RNA) · all NOTUM data types