Across TCGA patient cohorts, NOTUM mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOTUM-associated genes across cancer lineages are PKC-delta_pS664, Ku80, and Akt_pS473. Each is linked with NOTUM in more than 1 cancer types. Because this analysis shows association rather than direction, both NOTUM-to-partner and partner-to-NOTUM results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTUM→partner) and Y-score (partner→NOTUM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-delta_pS664 →	-0.127	-2.990	.015	.036	3	2
UCEC	Ku80 →	+0.239	+1.884	.020	.030	3	1
UCEC	Akt_pS473 →	+0.898	+2.807	.004	.003	3	1
UCEC	Akt_pT308 →	+0.743	+2.807	.006	.003	3	1
UCEC	p90 RSK →	+0.173	+2.999	.038	.035	3	1
UCEC	PKC-a_pS657 →	-0.345	-2.990	.039	.036	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

NOTUM survival (RNA) · tumor vs normal (RNA) · all NOTUM data types