Across TCGA cell cohorts, NOTCH4 mutation is significantly associated with the mutation status of many other genes, with 4,235 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NOTCH4-associated genes across cancer lineages are IL1RL2, SLX4, and PLXNB1. Each is linked with NOTCH4 in more than 6 cancer types. Because this analysis shows association rather than direction, both NOTCH4-to-partner and partner-to-NOTCH4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTCH4→partner) and Y-score (partner→NOTCH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IL1RL2 →	+4.297	+4.857	.009	.009	1	7
URINARY_TRACT	SLX4 →	+3.672	+4.307	.004	.004	1	6
SKIN	PLXNB1 →	+2.544	+1.963	.004	.004	1	6
OVARY	DCHS2 →	+2.204	+2.791	.005	.005	1	6
BLOOD_Leukemia	MAGEE1 →	+3.080	+2.675	.004	.004	1	6
BLOOD_Leukemia	OBSCN →	+1.417	+4.130	<.001	<.001	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,235 associations by consensus.

Exploration

NOTCH4 survival (RNA) · tumor vs normal (RNA) · all NOTCH4 data types