NOTCH3

Across TCGA pan-cancer cohorts, NOTCH3 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of NOTCH3’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where NOTCH3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types NOTCH3 is over-expressed in tumor.

PDAC, HNSC, and LSCC are the cancer types where NOTCH3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NOTCH3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	All	+0.666	<.001	8	view →
HNSC	Male	II,III,IV	+0.220	.004	8	view →
LSCC	Male	II,III,IV	+0.373	<.001	7	view →
LUAD	Male	All	+0.098	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

NOTCH3–PDAC

Open the PDAC breakdown →