NOTCH3

Across TCGA patient cohorts, NOTCH3 protein abundance is significantly associated with the RNA expression of many other genes, with 9,968 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NOTCH3-associated genes across cancer lineages are POSTN, LUM, and SYDE1. Each is linked with NOTCH3 in more than 5 cancer types. Because this analysis shows association rather than direction, both NOTCH3-to-partner and partner-to-NOTCH3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NOTCH3 versus POSTN in BRCA, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTCH3→partner) and Y-score (partner→NOTCH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	POSTN →	+1.996	+0.488	<.001	<.001	3	6
BRCA	LUM →	+1.852	+0.432	<.001	<.001	3	6
UCEC	SYDE1 →	+0.653	+0.354	<.001	<.001	3	6
CCRCC	ACTA2 →	+1.257	+0.724	<.001	.001	3	6
UCEC	ITGA11 →	+0.881	+0.369	<.001	<.001	3	6
LSCC	GPR161 →	+1.079	+0.421	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,968 associations by consensus.

NOTCH3 vs POSTN — BRCA

Explore this scatter interactively →