NOTCH3

Across TCGA cell cohorts, NOTCH3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,520 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible NOTCH3-associated GO terms across cancer lineages are Negative regulation of mRNA catabolic process, Positive regulation of mRNA metabolic process, and Negative regulation of mRNA metabolic process. Each is linked with NOTCH3 in more than 12 cancer types. Because this analysis shows association rather than direction, both NOTCH3-to-partner and partner-to-NOTCH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mRNA catabolic process grouped by NOTCH3-low versus NOTCH3-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTCH3→partner) and Y-score (partner→NOTCH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of mRNA catabolic process →	+0.072	+2.601	.001	<.001	3	13
SOFT_TISSUE	Positive regulation of mRNA metabolic process →	+0.046	+2.145	.006	.002	3	13
URINARY_TRACT	Negative regulation of mRNA metabolic process →	+0.096	+2.995	<.001	.001	3	12
PANCREAS	Post-transcriptional gene silencing →	+0.105	+1.396	<.001	.001	2	13
LARGE_INTESTINE	Negative regulation of mRNA splicing, via spliceosome →	+0.100	+1.805	<.001	<.001	3	12
OVARY	Heterochromatin formation →	+0.074	+2.186	<.001	.003	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,520 associations by consensus.

Negative regulation of mRNA catabolic process by NOTCH3 expression — LIVER

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