NOTCH3

Across TCGA cell cohorts, NOTCH3 mutation is significantly associated with the RNA expression of many other genes, with 1,549 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NOTCH3-associated genes across cancer lineages are LTA, GALNT9, and HSPH1. Each is linked with NOTCH3 in more than 2 cancer types. Because this analysis shows association rather than direction, both NOTCH3-to-partner and partner-to-NOTCH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LTA grouped by NOTCH3-low versus NOTCH3-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTCH3→partner) and Y-score (partner→NOTCH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	LTA →	+0.221	+3.160	<.001	.006	3	3
BLOOD_Leukemia	GALNT9 →	+0.603	+2.793	<.001	.002	3	3
LARGE_INTESTINE	HSPH1 →	-0.877	-2.584	<.001	.001	3	3
LARGE_INTESTINE	RAP1GDS1 →	+0.595	+2.290	<.001	<.001	3	3
LARGE_INTESTINE	H2AZ1 →	+0.615	+2.290	<.001	<.001	3	3
URINARY_TRACT	RIPPLY1 →	+0.391	+2.807	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,549 associations by consensus.

LTA by NOTCH3 expression — URINARY_TRACT

Explore this box plot interactively →