NOTCH2

Across TCGA pan-cancer cohorts, NOTCH2 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated NOTCH2 data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher NOTCH2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NOTCH2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

BRCA, UCEC, and LUSC are the cancer types where NOTCH2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	III,IV	0.131	0.833	<.001	20	view →
UCEC	DFS	Median	All	0.807	0.628	.013	14	view →
LUSC	OS	Median	All	1.000	0.662	.002	12	view →
KIRC	DFS	Median	All	0.127	0.865	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
LGG	OS	Median	All	0.317	0.799	.015	3	view →
SCLC	DFS	Median	II,III,IV	1.000	0.416	.026	1	view →
LUAD	DFS	Median	All	1.000	0.658	.044	1	view →
SKCM	OS	Median	II,III,IV	0.954	0.830	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

NOTCH2–BRCA (OS)

Open the BRCA breakdown →