NOTCH2

Across TCGA pan-cancer cohorts, NOTCH2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NOTCH2 data layer compared with 26 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NOTCH2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NOTCH2 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

CCRCC, COAD, and HNSC are the cancer types where NOTCH2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	0.574	0.907	.002	37	view →
COAD	DFS	Median	All	0.880	1.000	.028	18	view →
HNSC	DFS	Median	All	0.866	0.698	.010	11	view →
UCEC	OS	Median	III,IV	0.494	1.000	.016	8	view →
PDAC	DFS	Median	All	0.237	0.427	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NOTCH2–CCRCC (DFS)

Open the CCRCC breakdown →