NOSTRIN

Across TCGA patient cohorts, NOSTRIN protein abundance is significantly associated with the RNA expression of many other genes, with 19,392 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible NOSTRIN-associated genes across cancer lineages are CAVIN2, FHL5, and VSIG2. Each is linked with NOSTRIN in more than 8 cancer types. Because this analysis shows association rather than direction, both NOSTRIN-to-partner and partner-to-NOSTRIN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NOSTRIN versus CAVIN2 in CCRCC, with a Pearson correlation of 0.66.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOSTRIN→partner) and Y-score (partner→NOSTRIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CAVIN2 →	+1.125	+0.551	<.001	<.001	3	9
LSCC	FHL5 →	+1.109	+0.583	<.001	<.001	3	8
COAD	VSIG2 →	+2.544	+0.499	<.001	<.001	3	8
CCRCC	FAM110D →	+0.723	+0.419	<.001	<.001	3	8
UCEC	MYBL2 →	-1.480	-0.605	<.001	<.001	3	7
UCEC	FAM83D →	-1.259	-0.620	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,392 associations by consensus.

NOSTRIN vs CAVIN2 — CCRCC

Explore this scatter interactively →