NOSTRIN

Across TCGA pan-cancer cohorts, NOSTRIN RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of NOSTRIN’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where NOSTRIN RNA is repressed in tumor relative to normal tissue. In most cancer types NOSTRIN is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, BLCA, and LUSC are the cancer types where NOSTRIN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NOSTRIN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	IV	−2.906	<.001	11	view →
BLCA	Male	All	−1.081	<.001	11	view →
LUSC	Female	II,III,IV	−3.265	<.001	9	view →
LUAD	Female	III,IV	−2.072	<.001	9	view →
KIRP	All	III,IV	−1.173	<.001	9	view →
HNSC	Male	All	−0.887	<.001	8	view →
UCEC	All	All	−2.477	<.001	6	view →
BRCA	All	II,III,IV	−0.833	<.001	6	view →
KIRC	All	All	+0.501	<.001	5	view →
COAD	Female	All	−0.745	.001	4	view →
THCA	All	IV	−1.112	.009	3	view →
CHOL	Male	All	+0.953	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

NOSTRIN–KICH

Open the KICH breakdown →