NOSTRIN

Across TCGA patient cohorts, NOSTRIN mutation is significantly associated with the RNA expression of many other genes, with 2,467 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOSTRIN-associated genes across cancer lineages are RNU7-103P, TRAV31, and RMND1. Each is linked with NOSTRIN in more than 1 cancer types. Because this analysis shows association rather than direction, both NOSTRIN-to-partner and partner-to-NOSTRIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-103P grouped by NOSTRIN-low versus NOSTRIN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOSTRIN→partner) and Y-score (partner→NOSTRIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU7-103P →	+0.242	+4.408	<.001	.005	3	2
SKCM	TRAV31 →	+0.056	+4.039	<.001	.009	3	2
UCEC	RMND1 →	+0.543	+2.157	<.001	.009	3	2
UCEC	CHAF1B →	+0.658	+2.523	<.001	<.001	3	2
UCEC	ENTR1 →	+0.458	+2.180	<.001	<.001	3	2
UCEC	KIF22 →	+0.475	+3.938	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,467 associations by consensus.

RNU7-103P by NOSTRIN expression — SKCM

Explore this box plot interactively →