NOSTRIN

Across TCGA patient cohorts, NOSTRIN mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOSTRIN-associated genes across cancer lineages are Tuberin_pT1462, EGFR_pY1068, and A-Raf_pS299. Each is linked with NOSTRIN in more than 1 cancer types. Because this analysis shows association rather than direction, both NOSTRIN-to-partner and partner-to-NOSTRIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin_pT1462 grouped by NOSTRIN-low versus NOSTRIN-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOSTRIN→partner) and Y-score (partner→NOSTRIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Tuberin_pT1462 →	+0.199	+2.824	.020	.036	3	1
UCEC	EGFR_pY1068 →	-0.253	-2.000	.004	.003	3	1
UCEC	A-Raf_pS299 →	-0.103	-1.362	.015	.037	3	1
UCEC	ERK2 →	+0.138	+1.362	.042	.037	3	1
UCEC	JNK2 →	+0.173	+1.362	.013	.037	3	1
UCEC	MEK1 →	+0.326	+1.807	.011	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Tuberin_pT1462 by NOSTRIN expression — BLCA

Explore this box plot interactively →