NOSTRIN

Across TCGA cell cohorts, NOSTRIN mutation is significantly associated with the drug of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NOSTRIN-associated genes across cancer lineages are CP466722, AZD5991, and Dihydrorotenone. Each is linked with NOSTRIN in more than 1 cancer types. Because this analysis shows association rather than direction, both NOSTRIN-to-partner and partner-to-NOSTRIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CP466722 grouped by NOSTRIN-low versus NOSTRIN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOSTRIN→partner) and Y-score (partner→NOSTRIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CP466722 →	+0.424	+2.652	.032	.045	3	1
LARGE_INTESTINE	AZD5991 →	+0.878	+2.649	.021	.046	3	1
LARGE_INTESTINE	Dihydrorotenone →	+0.530	+2.649	.009	.046	3	1
LARGE_INTESTINE	FR-180204 →	+0.348	+2.652	.036	.045	3	1
LARGE_INTESTINE	NSC-207895 →	+0.493	+2.786	.022	.037	3	1
LARGE_INTESTINE	KIN001-244 →	+0.463	+2.652	.022	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

CP466722 by NOSTRIN expression — LARGE_INTESTINE

Explore this box plot interactively →