NOSIP

Across TCGA patient cohorts, NOSIP mutation is significantly associated with the RNA expression of many other genes, with 518 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOSIP-associated genes across cancer lineages are RNU4-58P, IGLVI-38, and LINC02342. Each is linked with NOSIP in more than 1 cancer types. Because this analysis shows association rather than direction, both NOSIP-to-partner and partner-to-NOSIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-58P grouped by NOSIP-low versus NOSIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOSIP→partner) and Y-score (partner→NOSIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-58P →	+0.180	+2.548	.007	.007	3	2
UCEC	IGLVI-38 →	+0.090	+2.424	.008	.005	3	2
BRCA	LINC02342 →	+0.188	+7.731	<.001	.009	3	1
BRCA	RN7SKP147 →	+0.178	+8.055	<.001	.007	3	1
BLCA	OR4A11P →	+0.337	+6.814	<.001	<.001	3	1
BLCA	OR8K2P →	+0.923	+6.147	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 518 associations by consensus.

RNU4-58P by NOSIP expression — UCEC

Explore this box plot interactively →