NOS3

Across TCGA patient cohorts, NOS3 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOS3-associated genes across cancer lineages are Caspase-7-cleavedD198, FOXO3a_pS318_S321, and ASNS. Each is linked with NOS3 in more than 3 cancer types. Because this analysis shows association rather than direction, both NOS3-to-partner and partner-to-NOS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by NOS3-low versus NOS3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOS3→partner) and Y-score (partner→NOS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.810	+2.708	.011	.003	3	4
UCEC	FOXO3a_pS318_S321 →	-0.088	-1.459	.029	.012	3	3
COAD	ASNS →	+0.435	+3.321	.006	.009	3	3
UCEC	Cyclin-B1 →	+0.711	+3.906	<.001	<.001	3	3
UCEC	eEF2 →	+0.274	+1.222	.018	.035	3	2
UCEC	A-Raf_pS299 →	-0.120	-1.584	.001	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

Caspase-7-cleavedD198 by NOS3 expression — COAD

Explore this box plot interactively →