NOS3

Across TCGA pan-cancer cohorts, NOS3 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of NOS3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NOS3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NOS3 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

COAD, HNSC, and STAD are the cancer types where NOS3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NOS3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	IV	+1.505	<.001	12	view →
HNSC	Female	III,IV	+1.150	<.001	10	view →
STAD	Male	II,III,IV	+1.377	<.001	8	view →
KIRP	Male	All	−1.892	<.001	7	view →
KICH	All	All	−1.309	<.001	6	view →
BLCA	All	All	−0.651	.014	5	view →
READ	All	All	+1.173	.002	4	view →
LUSC	All	All	−0.868	<.001	4	view →
BRCA	All	All	−0.401	<.001	4	view →
THCA	All	All	+0.483	<.001	3	view →
UCEC	All	All	−1.102	.005	2	view →
ESCA	All	All	+0.863	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

NOS3–COAD

Open the COAD breakdown →