NOS3

Across TCGA cell cohorts, NOS3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,782 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible NOS3-associated GO terms across cancer lineages are Response to cobalt ion, Mitochondrial potassium ion transmembrane transport, and Positive regulation of matrix metallopeptidase secretion. Each is linked with NOS3 in more than 6 cancer types. Because this analysis shows association rather than direction, both NOS3-to-partner and partner-to-NOS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to cobalt ion grouped by NOS3-low versus NOS3-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NOS3→partner) and Y-score (partner→NOS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Response to cobalt ion →	+0.102	+2.071	.001	.005	3	7
STOMACH	Mitochondrial potassium ion transmembrane transport →	+0.107	+2.909	.002	.001	3	7
BLOOD_Leukemia	Positive regulation of matrix metallopeptidase secretion →	+0.166	+1.563	.002	<.001	3	7
BLOOD_Myeloma	Response to interleukin-2 →	-0.232	-2.458	.003	.003	3	6
LUNG_SCLC	Regulation of ubiquitin protein ligase activity →	-0.124	-1.595	.009	.005	3	6
LUNG_SCLC	GDP-L-fucose biosynthetic process →	+0.079	+1.815	.005	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,782 associations by consensus.

Response to cobalt ion by NOS3 expression — SOFT_TISSUE

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