NOS3

Across TCGA cell cohorts, NOS3 mutation is significantly associated with the RNA expression of many other genes, with 1,087 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NOS3-associated genes across cancer lineages are SPATA5L1, NEURL4, and ST13. Each is linked with NOS3 in more than 2 cancer types. Because this analysis shows association rather than direction, both NOS3-to-partner and partner-to-NOS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA5L1 grouped by NOS3-low versus NOS3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOS3→partner) and Y-score (partner→NOS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SPATA5L1 →	+0.453	+2.158	<.001	.004	3	3
LARGE_INTESTINE	NEURL4 →	+0.711	+3.280	<.001	.003	3	3
LARGE_INTESTINE	ST13 →	+0.543	+2.158	<.001	.004	3	2
LARGE_INTESTINE	ERI1 →	+0.608	+2.158	.001	.004	3	2
LARGE_INTESTINE	RAD51C →	+0.727	+2.244	.005	.003	3	2
LARGE_INTESTINE	ZNF330 →	+0.439	+3.389	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,087 associations by consensus.

SPATA5L1 by NOS3 expression — LARGE_INTESTINE

Explore this box plot interactively →