NOS2

Across TCGA patient cohorts, NOS2 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOS2-associated genes across cancer lineages are ERK2, JNK2, and MEK1. Each is linked with NOS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOS2-to-partner and partner-to-NOS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by NOS2-low versus NOS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOS2→partner) and Y-score (partner→NOS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.156	+1.206	.003	.009	3	2
UCEC	JNK2 →	+0.197	+2.274	<.001	<.001	3	2
UCEC	MEK1 →	+0.407	+2.129	<.001	<.001	3	2
UCEC	Notch1 →	+0.129	+1.884	<.001	.001	3	2
UCEC	STAT3_pY705 →	-0.274	-1.353	<.001	.011	3	2
UCEC	TFRC →	+0.439	+2.906	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

ERK2 by NOS2 expression — UCEC

Explore this box plot interactively →