NOS2

Across TCGA pan-cancer cohorts, NOS2 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of NOS2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where NOS2 RNA is repressed in tumor relative to normal tissue. In most cancer types NOS2 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and UCEC are the cancer types where NOS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NOS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	III,IV	−1.223	<.001	11	view →
KIRP	Male	All	−0.885	<.001	9	view →
UCEC	All	II,III,IV	−0.473	.004	8	view →
LIHC	All	All	+0.606	<.001	7	view →
LUAD	Female	II,III,IV	−0.942	<.001	6	view →
KIRC	All	All	+0.575	<.001	5	view →
CHOL	All	All	+0.993	<.001	4	view →
THCA	All	All	+0.285	.005	2	view →
READ	Female	All	+1.380	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

NOS2–KICH

Open the KICH breakdown →