NOS2

Across TCGA cell cohorts, NOS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 909 significant associations in total. CNS shows the largest number of these associations.

The most reproducible NOS2-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, Positive regulation of DNA repair, and Positive regulation of double-strand break repair. Each is linked with NOS2 in more than 6 cancer types. Because this analysis shows association rather than direction, both NOS2-to-partner and partner-to-NOS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression, epigenetic grouped by NOS2-low versus NOS2-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NOS2→partner) and Y-score (partner→NOS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Negative regulation of gene expression, epigenetic →	+0.025	+0.364	.006	.006	3	7
OVARY	Positive regulation of DNA repair →	+0.057	+0.239	<.001	.009	3	7
OVARY	Positive regulation of double-strand break repair →	+0.067	+0.257	<.001	.005	3	7
LUNG_SCLC	tRNA transcription →	+0.092	+1.506	.002	.008	2	7
CNS	Heterochromatin organization →	+0.048	+0.396	.001	.005	2	7
SKIN	Heart process →	-0.065	-0.517	.007	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 909 associations by consensus.

Negative regulation of gene expression, epigenetic by NOS2 expression — SKIN

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