NOS2

Across TCGA cell cohorts, NOS2 mutation is significantly associated with the RNA expression of many other genes, with 980 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NOS2-associated genes across cancer lineages are PIP, DPPA5, and LEP. Each is linked with NOS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOS2-to-partner and partner-to-NOS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIP grouped by NOS2-low versus NOS2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOS2→partner) and Y-score (partner→NOS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PIP →	+0.339	+4.269	<.001	.005	3	2
LUNG_NSCLC_LUAD	DPPA5 →	+0.029	+2.959	.009	.004	3	2
SKIN	LEP →	+0.088	+2.994	.001	.006	3	2
LARGE_INTESTINE	CBX7 →	+0.717	+1.850	.003	.006	3	2
LARGE_INTESTINE	HFE →	+0.873	+2.364	<.001	<.001	3	2
LARGE_INTESTINE	FBXO6 →	+1.153	+1.850	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 980 associations by consensus.

PIP by NOS2 expression — LUNG_SCLC

Explore this box plot interactively →