NOP16

Across TCGA pan-cancer cohorts, NOP16 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NOP16 data layer compared with 30 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NOP16 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NOP16 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where NOP16 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.611	0.914	<.001	36	view →
HNSC	DFS	Tertile	All	0.633	0.823	.005	31	view →
LUAD	DFS	Median	II,III,IV	0.217	0.909	<.001	20	view →
UCEC	DFS	Tertile	III,IV	1.000	0.383	.016	16	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.596	.003	16	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NOP16–CCRCC (DFS)

Open the CCRCC breakdown →