NOP16

Across TCGA patient cohorts, NOP16 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOP16-associated genes across cancer lineages are eEF2, FoxM1, and STAT3_pY705. Each is linked with NOP16 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOP16-to-partner and partner-to-NOP16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by NOP16-low versus NOP16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOP16→partner) and Y-score (partner→NOP16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.541	+3.000	.008	.037	3	1
UCEC	FoxM1 →	+0.320	+3.000	.032	.037	3	1
UCEC	STAT3_pY705 →	-0.497	-3.000	.001	.037	2	1
UCEC	c-Kit →	-0.309	-3.000	.022	.037	2	1
UCEC	MEK1 →	+0.538	+3.000	.010	.037	1	1
UCEC	PCNA →	+0.362	+3.000	.003	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

eEF2 by NOP16 expression — UCEC

Explore this box plot interactively →