NOP10

Across TCGA pan-cancer cohorts, NOP10 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NOP10 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NOP10 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NOP10 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

UCEC, CCRCC, and PDAC are the cancer types where NOP10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.433	1.000	.007	14	view →
CCRCC	DFS	Median	All	0.704	1.000	.008	6	view →
PDAC	OS	Median	IV	0.836	0.491	.024	6	view →
LUAD	DFS	Quartile	All	0.867	0.686	.028	6	view →
OV	DFS	Median	All	0.682	0.923	.048	4	view →
LSCC	DFS	Quartile	II,III,IV	0.927	0.605	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NOP10–UCEC (OS)

Open the UCEC breakdown →