NOL4

Across TCGA patient cohorts, NOL4 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOL4-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and MSH2. Each is linked with NOL4 in more than 3 cancer types. Because this analysis shows association rather than direction, both NOL4-to-partner and partner-to-NOL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by NOL4-low versus NOL4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOL4→partner) and Y-score (partner→NOL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Caspase-7-cleavedD198 →	+0.617	+2.824	.017	.036	3	4
COAD	eIF4E →	+0.188	+3.012	.012	.018	3	4
SKCM	MSH2 →	+0.147	+1.169	.043	.033	3	2
UCEC	EGFR_pY1068 →	-0.161	-0.874	.012	.036	3	2
UCEC	Fibronectin →	-0.167	-1.054	.048	.043	3	2
UCEC	MEK1 →	+0.373	+2.459	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Caspase-7-cleavedD198 by NOL4 expression — LUAD

Explore this box plot interactively →